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The liver metabolizes alcohol at a relatively constant rate, and the body requires time for this process

Its composition is designed to mimic the action of endogenous neurotrophic factors, making it a powerful agent for neuroprotection and repair

Front Immunol (2022) 13:931087

Jacobson A, Lam L, Rajendram M, Tamburini F, Honeycutt J, Pham T, Van Treuren W, Pruss K, Stabler SR, Lugo K, Bouley DM, Vilches-Moure JG, Smith M, Sonnenburg JL, Bhatt AS, Huang KC, Monack D (2018) A gut commensal-produced metabolite mediates colonization resistance to salmonella infection

Although these findings do not completely exclude the effect on kidney parenchymal cells or off-target effects, these results suggest that sulfasalazine prevents the formation of TLS not by attenuating tubular injury but via its inhibitory effect on of the cystine/glutamate transporter specifically expressed within TLS

While these findings are encouraging, its important for our patients to understand that robust human clinical trials are still lacking